Product Name: 3-Isocyanate Propyl Methyl Dimethoxy Silane
Synonyms: 3-Isocyanatopropyltrimethoxysilane, Isocyanatopropylsilane
CAS Number: 15396-00-6
Manufacturer: Refer to supplier information
Recommended Use: Industrial intermediate for surface modification and coupling agent applications
Emergency Contact: Local emergency number or Poison Control
Chemical Family: Alkoxysilane, organoisocyanate
Classification: Acute Toxicity (Oral, Dermal, Inhalation), Skin Corrosion/Irritation, Serious Eye Damage/Irritation, Respiratory Sensitization, Skin Sensitization, Specific Target Organ Toxicity (Single Exposure)
Pictograms: Health hazard (exclamation mark, corrosive, respiratory)
Signal Word: Danger
Hazard Statements: Harmful if swallowed, toxic in contact with skin, causes severe skin burns and eye damage, may cause allergy or asthma symptoms or breathing difficulties, may cause an allergic skin reaction, harmful by inhalation
Precautionary Statements: Avoid breathing vapors, wear protective equipment, wash thoroughly after handling, use only outdoors or in well-ventilated area, avoid release to the environment
Chemical Name: 3-Isocyanate Propyl Methyl Dimethoxy Silane
CAS Number: 15396-00-6
Concentration: 96 - 99%
Impurities and Stabilizing Additives: May contain traces of other silanes or unreacted material (<1%); contact supplier for full impurity profile
General: Remove victim to fresh air and keep at rest. Seek immediate medical advice.
Inhalation: Move person to fresh air. Oxygen or artificial respiration if necessary. Obtain medical attention.
Skin Contact: Remove contaminated clothing. Wash affected skin with plenty of soap and water for at least 15 minutes. Do not reuse clothing until laundered. Seek medical attention.
Eye Contact: Rinse thoroughly with water for at least 15 minutes, keeping eyelids open. Remove contact lenses if present. Immediate medical attention required.
Ingestion: Rinse mouth. Do not induce vomiting. Give water to drink if conscious. Immediate hospitalization suggested.
Potential Symptoms: Respiratory tract irritation, asthma-like symptoms, burning of skin or eyes, gastrointestinal irritation, allergic reactions
Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam
Unsuitable Extinguishing Media: Water jet (may spread fire)
Specific Hazards: May release toxic fumes such as nitrogen oxides, carbon oxides, silicon oxides, hydrogen cyanide upon combustion
Protective Equipment: Wear full-body chemical-resistant suit and self-contained breathing apparatus
Advice for Firefighters: Stay upwind, use water spray to cool containers exposed to flame, control run-off to prevent entry into water systems
Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides, silicon dioxide, hydrogen cyanide
Personal Precautions: Use personal protective equipment, avoid contact with skin, eyes, and clothing, ensure adequate ventilation
Environmental Precautions: Prevent further leakage or spillage if safe, do not let chemical enter water sources, sewers or soil
Methods for Cleanup: Cover spill with inert absorbent (sand, earth, vermiculite) and collect into suitable, labeled closed containers for disposal. Large spills may require area evacuation.
Decontamination: Wash spill area with sodium bicarbonate solution, ventilate area
Additional Advice: Immediately inform responsible authorities if environmental contamination occurs.
Handling: Follow strict industrial hygiene practices, keep container tightly closed. Handle in compliance with chemical hygiene protocol. Do not eat, drink, or smoke working with product.
Precautions: Avoid inhalation of vapors, prevent skin and eye contact. Avoid exposure to heat, sparks, and open flame.
Storage: Store in original, tightly closed container at a dry, well-ventilated location, away from direct sunlight and incompatible chemicals such as water, acids, and bases.
Recommended Storage Conditions: 2-8°C, away from moisture and light, upright to avoid leaks
Packaging Materials: Use corrosion-resistant, tightly sealed containers; glass or lined steel recommended.
Incompatibilities: Avoid water, alcohols, strong acids, bases, and oxidizers.
Occupational Exposure Limits: Consult local authority or supplier—no established exposure limits on NIOSH/OSHA but treat as hazardous.
Engineering Controls: Use only in a chemical fume hood; provide forced ventilation in work area.
Personal Protective Equipment: Respiratory protection (NIOSH-approved respirator), chemical-resistant gloves (nitrile or neoprene), chemical-resistant goggles, face shield, full-length lab coat or coveralls.
Hygiene Measures: Wash thoroughly after handling, keep contaminated clothing separate, launder before reuse. Do not take contaminated clothing home.
Environmental Controls: Contain fugitive emissions at source, use spill containment systems in storage and transfer areas.
Appearance: Colorless to pale yellow liquid
Odor: Pungent, acrid
Odor Threshold: Not available
pH: Not applicable (reacts with water)
Melting Point / Freezing Point: -
Boiling Point/Range: Approx. 168°C at 760 mmHg
Flash Point: 68°C (closed cup)
Evaporation Rate: Not determined
Flammability (solid/gas): Not applicable
Upper/Lower Flammability or Explosive Limits: Not determined
Vapor Pressure: 0.5 mmHg at 20°C
Vapor Density: Not available
Relative Density: 1.02 g/cm³ at 25°C
Solubility: Reacts with water with release of carbon dioxide and heat; soluble in organic solvents (e.g., ethanol, toluene)
Partition coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: Not determined
Decomposition Temperature: Not determined
Viscosity: Low
Chemical Stability: Stable under recommended storage conditions.
Reactivity: Reacts violently with water, alcohols, strong acids, and bases.
Hazardous Reactions: Contact with moisture liberates highly toxic and reactive isocyanates and methanol; reacts exothermically with water.
Conditions to Avoid: Exposure to moisture, heat, and direct sunlight.
Incompatible Materials: Water, alcohols, oxidizing agents, bases, acids.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen cyanide, silicon oxides, methanol.
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion.
Acute Toxicity: Harmful—oral (ATE ≤ 500 mg/kg), dermal (ATE ≤ 600 mg/kg), inhalation (ATE ≤ 1.5 mg/L inhalation vapor)
Skin Irritation: Severe burns may result from exposure; may cause blistering and ulceration.
Eye Damage: Risk of serious and potentially irreversible eye damage.
Respiratory Sensitization: May trigger asthma-like reactions or sensitization.
Skin Sensitization: May produce allergic contact dermatitis after repeated or prolonged exposure.
Chronic Effects: Chronic inhalation may result in decreased lung function, asthma, and other respiratory impairments.
Mutagenicity/Carcinogenicity/Reproductive Toxicity: Based on similar isocyanates: not conclusive but not ruled out without further data.
Aquatic Toxicity: Harmful to aquatic life, may cause long-term adverse effects in aquatic environments.
Degradability: Hydrolyzes readily in water to form silanols and methanol; silanols polymerize forming insoluble silica.
Bioaccumulation Potential: Not expected to bioaccumulate significantly.
Mobility: Reacts with water and soil moisture, limited mobility as hydrolysis product.
Additional Information: Spillages must not drain into surface waters or sanitary sewers; observe local discharge regulations.
Product Disposal: Must be treated as hazardous chemical waste. Incinerate at approved facility in accordance with local, regional, and national regulations.
Contaminated Packaging: Dispose of containers thoroughly cleaned and compliant with hazardous waste protocols.
Methods: Neutralize residues using sodium bicarbonate or similar reactant under controlled conditions, then collect for approved waste disposal.
Disposal Precautions: Do not landfill untreated product, do not flush to sewer.
UN Number: 2810
Proper Shipping Name: Toxic liquid, organic, n.o.s. (contains 3-isocyanate propyl methyl dimethoxy silane)
Transport Hazard Class: 6.1 (toxic substances)
Packing Group: II
Marine Pollutant: Yes (contains hazardous substances for aquatic life)
Environmental Hazards: Avoid release to waterways
Special Precautions: Secure packaging, appropriate labeling, transport with ERP available
Transport Regulations: Comply with IMDG, IATA, ADR/RID as appropriate for international carriage.
Labelling Requirements: GHS, OSHA Hazard Communication, EU CLP Regulation
Inventory Listings: Listed or notified as required by national or regional legislation (consult local chemical inventories: TSCA (US), EINECS (EU), DSL (CA), ENCS (JP), others)
REACH Status: May require registration or authorization for import, manufacture, and use in EU.
SARA Title III: Listed under Section 313 if applicable (Check manufacturer’s SDS)
Worker Protection: Covered under OSHA chemical safety standard, worker’s right-to-know, and mandated training requirements.
Other Regulations: Waste classified as hazardous; carriers and disposal must comply with EPA and RCRA. Local and regional regulations may impose additional restrictions. Always refer to most current regulatory data for compliance.
